Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration

Mutations in human prominin 1 (PROM1), encoding a transmembrane glycoprotein localized mainly to plasma membrane protrusions, have been reported to cause retinitis pigmentosa, macular degeneration, and cone–rod dystrophy. Although the structural role of PROM1 in outer-segment (OS) morphogenesis has...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lu, Zhaojing, Hu, Xuebin, Reilly, James, Jia, Danna, Liu, Fei, Yu, Shanshan, Liu, Xiliang, Xie, Shanglun, Qu, Zhen, Qin, Yayun, Huang, Yuwen, Lv, Yuexia, Li, Jingzhen, Gao, Pan, Wong, Fulton, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755801/
https://ncbi.nlm.nih.gov/pubmed/31362982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008618
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