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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3(−/−) mouse embryonic fibroblasts have a reduction in basal ATP levels. Reconstitution with wild-type but...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567183/ https://ncbi.nlm.nih.gov/pubmed/18794531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803790105 |
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