A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3(−/−) mouse embryonic fibroblasts have a reduction in basal ATP levels. Reconstitution with wild-type but...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ahn, Bong-Hyun, Kim, Hyun-Seok, Song, Shiwei, Lee, In Hye, Liu, Jie, Vassilopoulos, Athanassios, Deng, Chu-Xia, Finkel, Toren
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567183/
https://ncbi.nlm.nih.gov/pubmed/18794531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803790105
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