Design of highly specific cytotoxins by using trans-splicing ribozymes
We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
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| المؤلفون الرئيسيون: | , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1999
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3507 |
| الوسوم: |
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