Design of highly specific cytotoxins by using trans-splicing ribozymes

We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Ayre, Brian G., Köhler, Uwe, Goodman, Howard M., Haseloff, Jim
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1999
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3507
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