Design of highly specific cytotoxins by using trans-splicing ribozymes
We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3507 |
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