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Design of highly specific cytotoxins by using trans-splicing ribozymes
We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...
Wedi'i Gadw mewn:
Prif Awduron: | , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
The National Academy of Sciences
1999
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC22323/ https://ncbi.nlm.nih.gov/pubmed/10097066 |
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