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Design of highly specific cytotoxins by using trans-splicing ribozymes

We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ayre, Brian G., Köhler, Uwe, Goodman, Howard M., Haseloff, Jim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC22323/
https://ncbi.nlm.nih.gov/pubmed/10097066
Tagiau: Ychwanegu Tag
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