Design of highly specific cytotoxins by using trans-splicing ribozymes

We have designed ribozymes based on a self-splicing group I intron that can trans-splice exon sequences into a chosen RNA target to create a functional chimeric mRNA and provide a highly specific trigger for gene expression. We have targeted ribozymes against the coat protein mRNA of a widespread pl...

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Bibliographic Details
Main Authors: Ayre, Brian G., Köhler, Uwe, Goodman, Howard M., Haseloff, Jim
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC22323/
https://ncbi.nlm.nih.gov/pubmed/10097066
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