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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an HCV replicon assay. The 5′-triphosphate of PSI-6130 is a competitive inhibitor of the HCV RNA-dependent RNA polymerase (RdRp) and acts as a nonobligate chain terminator. Recen...

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Hlavní autoři: Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224766/
https://ncbi.nlm.nih.gov/pubmed/17999967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01184-07
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