Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway

The peptides derived from the heptad repeat (HRP) of severe acute respiratory syndrome coronavirus (SCoV) spike protein (sHRPs) are known to inhibit SCoV infection, yet their efficacies are fairly low. Recently our research showed that some proteases facilitated SCoV's direct entry from the cel...

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Main Authors: Ujike, Makoto, Nishikawa, Hiroki, Otaka, Akira, Yamamoto, Naoki, Yamamoto, Norio, Matsuoka, Masao, Kodama, Eiichi, Fujii, Nobutaka, Taguchi, Fumihiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224400/
https://ncbi.nlm.nih.gov/pubmed/17942557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01697-07
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