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Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling

The environmental toxin 2,3,7,8-tetrachlorodibenzodioxin (TCDD) is a known human carcinogen; however, its precise mechanism of action remains unclear. Here we show that TCDD induces mitochondrial dysfunction, stress signaling, and tumor invasion by a mechanism similar to that described for mtDNA-dep...

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Bibliografiske detaljer
Main Authors: Biswas, Gopa, Srinivasan, Satish, Anandatheerthavarada, Hindupur K., Avadhani, Narayan G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224183/
https://ncbi.nlm.nih.gov/pubmed/18172213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706183104
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