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Bimodal Targeting of Microsomal CYP2E1 to Mitochondria through Activation of an N-terminal Chimeric Signal by cAMP-mediated Phosphorylation

Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol-induced toxicity and oxidative stress. Recently, we showed that this predominantly microsomal protein is also localized in rat hepatic mitochondria. In this report, we show that the N-terminal 30 amino acids of CYP2E1 contain a chimeric...

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書誌詳細
主要な著者: Robin, Marie-Anne, Anandatheerthavarada, Hindupur K., Biswas, Gopa, Sepuri, Naresh Babu V., Gordon, Donna M., Pain, Debkumar, Avadhani, Narayan G.
フォーマット: Artigo
言語:Inglês
出版事項: 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800117/
https://ncbi.nlm.nih.gov/pubmed/12191992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M203292200
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