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Mitochondria to nucleus stress signaling: a distinctive mechanism of NFκB/Rel activation through calcineurin-mediated inactivation of IκBβ

Mitochondrial genetic and metabolic stress causes activation of calcineurin (Cn), NFAT, ATF2, and NFκB/Rel factors, which collectively alter the expression of an array of nuclear genes. We demonstrate here that mitochondrial stress–induced activation of NFκB/Rel factors involves inactivation of IκBβ...

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Main Authors: Biswas, Gopa, Anandatheerthavarada, Hindupur K., Zaidi, Mone, Avadhani, Narayan G.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172940/
https://ncbi.nlm.nih.gov/pubmed/12732617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200211104
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