Mechanisms by Which the G333D Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Facilitates Dual Resistance to Zidovudine and Lamivudine

Recent studies have identified a role for mutations in the connection and RNase H domains of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance to nucleoside analog RT inhibitors (NRTI). To provide insight into the biochemical mechanism(s) involved, we investigated the...

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Detalhes bibliográficos
Main Authors: Zelina, Shannon, Sheen, Chih-Wei, Radzio, Jessica, Mellors, John W., Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223917/
https://ncbi.nlm.nih.gov/pubmed/17967907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00904-07
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