Molecular Mechanism by Which the K70E Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Nucleoside Reverse Transcriptase Inhibitors

The K70E mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has become more prevalent in clinical samples, particularly in isolates derived from patients for whom triple-nucleoside regimens that include tenofovir (TNV), abacavir, and lamivudine (3TC) failed. To elucid...

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Detalhes bibliográficos
Main Authors: Sluis-Cremer, Nicolas, Sheen, Chih-Wei, Zelina, Shannon, Torres, Pedro S. Argoti, Parikh, Urvi M., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797654/
https://ncbi.nlm.nih.gov/pubmed/17088490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00683-06
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