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A Novel Polymorphism at Codon 333 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Can Facilitate Dual Resistance to Zidovudine and l-2′,3′-Dideoxy-3′-Thiacytidine

Recent clinical trials examining 3′-azido-3′-deoxythymidine (AZT, zidovudine, or Retrovir) combined with l-2′,3′-dideoxy-3′-thiacytidine (3TC or lamivudine) have shown that combination therapy with these nucleoside analogs affords significant virological and clinical benefits. The addition of 3TC to...

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Bibliografski detalji
Glavni autori: Kemp, Sharon D., Shi, Chaofu, Bloor, Stuart, Harrigan, P. Richard, Mellors, John W., Larder, Brendan A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC110074/
https://ncbi.nlm.nih.gov/pubmed/9573280
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