A Novel Polymorphism at Codon 333 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Can Facilitate Dual Resistance to Zidovudine and l-2′,3′-Dideoxy-3′-Thiacytidine

Recent clinical trials examining 3′-azido-3′-deoxythymidine (AZT, zidovudine, or Retrovir) combined with l-2′,3′-dideoxy-3′-thiacytidine (3TC or lamivudine) have shown that combination therapy with these nucleoside analogs affords significant virological and clinical benefits. The addition of 3TC to...

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Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	Kemp, Sharon D., Shi, Chaofu, Bloor, Stuart, Harrigan, P. Richard, Mellors, John W., Larder, Brendan A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1998
Предметы:	Animal Viruses
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573280/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.5093-5098.1998
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