A Novel Point Mutation at Position 156 of Reverse Transcriptase from Feline Immunodeficiency Virus Confers Resistance to the Combination of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine and 3′-Azido-3′-Deoxythymidine

Mutants of feline immunodeficiency virus (FIV) resistant to (−)-β-2′,3′-dideoxy-3′-thiacytidine (3TC) were selected by culturing virus in the presence of increasing stepwise concentrations of 3TC. Two plaque-purified variants were isolated from the original mutant population, and both of these mutan...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Smith, Robert A., Remington, Kathryn M., Preston, Bradley D., Schinazi, Raymond F., North, Thomas W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Animal Viruses
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499094/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.3.2335-2340.1998
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