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A New Point Mutation (P157S) in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Confers Low-Level Resistance to (−)-β-2′,3′-Dideoxy-3′-Thiacytidine

A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (−)-β-2′,3′-dideoxy-3′-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3′-azido-3′-deoxythymidine (AZT)...

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Autori principali: Smith, Robert A., Klarmann, George J., Stray, Kirsten M., von Schwedler, Uta K., Schinazi, Raymond F., Preston, Bradley D., North, Thomas W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89420/
https://ncbi.nlm.nih.gov/pubmed/10428942
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