UBIQUITINATION OF β-ARRESTIN LINKS 7-TRANSMEMBRANE RECEPTOR ENDOCYTOSIS AND ERK ACTIVATION

β-arrestin2 and its ubiquitination play crucial roles in both internalization and signaling of seven-transmembrane receptors (7TMRs). To understand the connection between ubiquitination and β-arrestin’s endocytic and signaling functions, we generated a β-arrestin2 mutant that is defective in ubiquit...

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Main Authors: Shenoy, Sudha K., Barak, Larry S., Xiao, Kunhong, Ahn, Seungkirl, Berthouze, Magali, Shukla, Arun K., Luttrell, Louis M., Lefkowitz, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2216744/
https://ncbi.nlm.nih.gov/pubmed/17666399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700852200
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