Application of high-throughput screening to identify a novel αIIb-specific small- molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen

Lignende værker

• Ligand density dramatically affects integrin αIIbβ3-mediated platelet signaling and spreading
  af: Jiroušková, Markéta, et al.
  Udgivet: (2007)
• Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel αIIb-specific αIIbβ3 antagonist
  af: Blue, Robert, et al.
  Udgivet: (2009)
• Mapping early conformational changes in αIIb and β3 during biogenesis reveals a potential mechanism for αIIbβ3 adopting its bent conformation
  af: Beau Mitchell, W., et al.
  Udgivet: (2007)
• Effects of Limiting Extension at the αIIb Genu on Ligand Binding to Integrin αIIbβ3
  af: Blue, Robert, et al.
  Udgivet: (2010)
• αIIbβ3 biogenesis is controlled by engagement of αIIb in the calnexin cycle via the N15-linked glycan
  af: Mitchell, W. Beau, et al.
  Udgivet: (2006)