The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases. We have explored the role of the phosphoinositol(3,4,5)P3-phosphatase PTEN in T cell development by analyzing mice with a T cell–specific d...

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Detalhes bibliográficos
Main Authors: Hagenbeek, Thijs J., Naspetti, Marianne, Malergue, Fabrice, Garçon, Fabien, Nunès, Jacques A., Cleutjens, Kitty B.J.M., Trapman, Jan, Krimpenfort, Paul, Spits, Hergen
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213281/
https://ncbi.nlm.nih.gov/pubmed/15452180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040495
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