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Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
CD4((+))CD8((+)) “double positive” (DP) thymocytes differentiate into diverse αβ T cell sub-types using mechanistically distinct programs. For example, conventional αβ T cells develop from DP cells after partial-agonist T cell receptor (TCR) interactions with self-peptide/MHC, whereas unconventional...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587556/ https://ncbi.nlm.nih.gov/pubmed/28878277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09368-x |
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