Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes

CD4((+))CD8((+)) “double positive” (DP) thymocytes differentiate into diverse αβ T cell sub-types using mechanistically distinct programs. For example, conventional αβ T cells develop from DP cells after partial-agonist T cell receptor (TCR) interactions with self-peptide/MHC, whereas unconventional...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Grandjean, Capucine L., Sumaria, Nital, Martin, Stefania, Pennington, Daniel J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587556/
https://ncbi.nlm.nih.gov/pubmed/28878277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09368-x
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