Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

Adaptive cellular immunity requires accurate self- vs. nonself-discrimination to protect against infections and tumorous transformations while at the same time excluding autoimmunity. This vital capability is programmed in the thymus through selection of αβT-cell receptors (αβTCRs) recognizing pepti...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mallis, Robert J., Bai, Ke, Arthanari, Haribabu, Hussey, Rebecca E., Handley, Maris, Li, Zhenhai, Chingozha, Loice, Duke-Cohan, Jonathan S., Lu, Hang, Wang, Jia-Huai, Zhu, Cheng, Wagner, Gerhard, Reinherz, Ellis L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500245/
https://ncbi.nlm.nih.gov/pubmed/26056289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504971112
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