NMR-directed design of pre-TCRβ and pMHC molecules implies a distinct geometry for pre-TCR relative to αβTCR recognition of pMHC

The pre-T cell receptor (pre-TCR) guides early thymocytes through maturation processes within the thymus via interaction with self-ligands displayed on thymic epithelial cells. The pre-TCR is a disulfide-linked heterodimer composed of an invariant pre-TCR α (pTα) subunit and a variable β subunit, th...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Mallis, Robert J., Arthanari, Haribabu, Lang, Matthew J., Reinherz, Ellis L., Wagner, Gerhard
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777251/
https://ncbi.nlm.nih.gov/pubmed/29101227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813493
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