Pre–T cell receptors topologically sample self-ligands during thymocyte β-selection

Self-discrimination, a critical but ill-defined molecular process programmed during thymocyte development, requires myriad pre–T cell receptors (preTCRs) and αβTCRs. Using x-ray crystallography, we show how a preTCR applies the concave β-sheet surface of its single variable domain (Vβ) to “horizonta...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Li, Xiaolong, Mizsei, Réka, Tan, Kemin, Mallis, Robert J., Duke-Cohan, Jonathan S., Akitsu, Aoi, Tetteh, Paul W., Dubey, Abhinav, Hwang, Wonmuk, Wagner, Gerhard, Lang, Matthew J., Arthanari, Haribabu, Wang, Jia-huai, Reinherz, Ellis L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011828/
https://ncbi.nlm.nih.gov/pubmed/33335016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe0918
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