Multiple event activation of a generic prodrug trigger by antibody catalysis

Chemotherapeutic regimes are typically limited by nonspecific toxicity. To address this problem we have developed a broadly applicable drug-masking chemistry that operates in conjunction with a unique broad-scope catalytic antibody. This masking chemistry is applicable to a wide range of drugs becau...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shabat, Doron, Rader, Christoph, List, Benjamin, Lerner, Richard A., Barbas, Carlos F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22018/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359815/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6925
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