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Prodrug activation via catalytic antibodies.

Prodrug activation via antibodies was examined by using the antibiotic chloramphenicol as a model drug. Based on the conformational change between substrate and product, this antibody-catalyzed reaction was designed to prevent product inhibition, thus enhancing turnover. Antibodies elicited against...

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Detalhes bibliográficos
Main Authors: Miyashita, H, Karaki, Y, Kikuchi, M, Fujii, I
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46711/
https://ncbi.nlm.nih.gov/pubmed/8506382
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