Prodrug activation via catalytic antibodies.
Prodrug activation via antibodies was examined by using the antibiotic chloramphenicol as a model drug. Based on the conformational change between substrate and product, this antibody-catalyzed reaction was designed to prevent product inhibition, thus enhancing turnover. Antibodies elicited against...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506382/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.11.5337 |
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