Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies.

The x-ray structure of the complex of a catalytic antibody Fab fragment with a phosphonate transition-state analog has been determined. The antibody (CNJ206) catalyzes the hydrolysis of p-nitrophenyl esters with significant rate enhancement and substrate specificity. Comparison of this structure wit...

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Hauptverfasser: Charbonnier, J B, Carpenter, E, Gigant, B, Golinelli-Pimpaneau, B, Eshhar, Z, Green, B S, Knossow, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40474/
https://ncbi.nlm.nih.gov/pubmed/8524836
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