Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.

Antibody-directed enzyme prodrug therapy, ADEPT, is a recent approach to targeted cancer chemotherapy intended to diminish the nonspecific toxicity associated with many commonly used chemotherapeutic agents. Most ADEPT systems incorporate a bacterial enzyme, and thus their potential is reduced becau...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wentworth, P, Datta, A, Blakey, D, Boyle, T, Partridge, L J, Blackburn, G M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.799
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