Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)

The immunomodulator FTY720 (FTY) has been shown to be beneficial in experimental models of organ transplantation and autoimmunity. We show that FTY significantly inhibited but did not prevent graft-versus-host disease (GVHD) in lethally irradiated or nonirradiated allogeneic recipients. Although mos...

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Hlavní autoři: Taylor, Patricia A., Ehrhardt, Michael J., Lees, Christopher J., Tolar, Jakub, Weigel, Brenda J., Panoskaltsis-Mortari, Angela, Serody, Jonathan S., Brinkmann, Volker, Blazar, Bruce R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200903/
https://ncbi.nlm.nih.gov/pubmed/17606761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-087940
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