Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)

The immunomodulator FTY720 (FTY) has been shown to be beneficial in experimental models of organ transplantation and autoimmunity. We show that FTY significantly inhibited but did not prevent graft-versus-host disease (GVHD) in lethally irradiated or nonirradiated allogeneic recipients. Although mos...

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Détails bibliographiques
Auteurs principaux: Taylor, Patricia A., Ehrhardt, Michael J., Lees, Christopher J., Tolar, Jakub, Weigel, Brenda J., Panoskaltsis-Mortari, Angela, Serody, Jonathan S., Brinkmann, Volker, Blazar, Bruce R.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2007
Sujets:
Transplantation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200903/
https://ncbi.nlm.nih.gov/pubmed/17606761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-087940
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