Dendritic Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides to Act as an Adjuvant for Protective Vaccine Immunity Against Leishmania major in Mice

Vaccination with leishmanial Ag and CpG oligodeoxynucleotides (ODN) confers sustained cellular immunity and protection to infectious challenge up to 6 mo after immunization. To define the cellular mechanism by which CpG ODN mediate their adjuvant effects in vivo, the functional capacity of distinct...

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Main Authors: Shah, Javeed A., Darrah, Patricia A., Ambrozak, David R., Turon, Tara N., Mendez, Susana, Kirman, Joanna, Wu, Chang-You, Glaichenhaus, Nicolas, Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194077/
https://ncbi.nlm.nih.gov/pubmed/12874261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030645
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