Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-Term Memory CD4(+)and CD8(+)T Cell Responses and Protection Against Leishmania major Infection

CpG oligodeoxynucleotides (ODN) have potent effects on innate and adaptive cellular immune responses. In this report, the ability of CpG ODN to confer long-term immunity and protection when used as a vaccine adjuvant with a clinical grade of leishmanial antigen, autoclaved Leishmania major (ALM), or...

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Detalhes bibliográficos
Main Authors: Rhee, Elizabeth G., Mendez, Susana, Shah, Javeed A., Wu, Chang-you, Kirman, Joanna R., Turon, Tara N., Davey, Dylan F., Davis, Heather, Klinman, Dennis M., Coler, Rhea N., Sacks, David L., Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193566/
https://ncbi.nlm.nih.gov/pubmed/12070284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020147
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