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Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B(4) synthetic capacity

The enzyme 5-lipoxygenase (5-LO) initiates the synthesis of leukotrienes from arachidonic acid. In resting cells, 5-LO can accumulate in either the cytoplasm or the nucleoplasm and, upon cell stimulation, translocates to membranes to initiate leukotriene synthesis. Here, we used mutants of 5-LO with...

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Sonraí Bibleagrafaíochta
Main Authors: Luo, Ming, Jones, Sandra M., Peters-Golden, Marc, Brock, Thomas G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC218730/
https://ncbi.nlm.nih.gov/pubmed/14530386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2133253100
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