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Phosphorylation of Serine 271 on 5-Lipoxygenase and Its Role in Nuclear Export

The enzyme 5-lipoxygenase (5-LO) initiates the biosynthesis of leukotrienes, inflammatory mediators involved in immune diseases and defense. The subcellular localization of 5-LO is regulated, with nuclear import commonly leading to increased leukotriene production. We report here that 5-LO is consti...

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Detalles Bibliográficos
Main Authors: Flamand, Nicolas, Luo, Ming, Peters-Golden, Marc, Brock, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610501/
https://ncbi.nlm.nih.gov/pubmed/18978352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805593200
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