Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

Sphingomyelin (SM) is one of the major lipid components of plasma lipoproteins. Serine palmitoyltransferase (SPT) is the key enzyme in SM biosynthesis. Mice totally lacking in SPT are embryonic lethal. The liver is the major site for plasma lipoprotein biosynthesis, secretion, and degradation, and i...

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Bibliografiset tiedot
Päätekijät: Li, Zhiqiang, Li, Yan, Chakraborty, Mahua, Fan, Yifan, Bui, Hai H., Peake, David A., Kuo, Ming-Shang, Xiao, Xiao, Cao, Guoqing, Jiang, Xian-Cheng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785386/
https://ncbi.nlm.nih.gov/pubmed/19648608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042028
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