Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

Sphingomyelin (SM) is one of the major lipid components of plasma lipoproteins. Serine palmitoyltransferase (SPT) is the key enzyme in SM biosynthesis. Mice totally lacking in SPT are embryonic lethal. The liver is the major site for plasma lipoprotein biosynthesis, secretion, and degradation, and i...

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Hlavní autoři: Li, Zhiqiang, Li, Yan, Chakraborty, Mahua, Fan, Yifan, Bui, Hai H., Peake, David A., Kuo, Ming-Shang, Xiao, Xiao, Cao, Guoqing, Jiang, Xian-Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785386/
https://ncbi.nlm.nih.gov/pubmed/19648608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042028
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