Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

Sphingomyelin (SM) is one of the major lipid components of plasma lipoproteins. Serine palmitoyltransferase (SPT) is the key enzyme in SM biosynthesis. Mice totally lacking in SPT are embryonic lethal. The liver is the major site for plasma lipoprotein biosynthesis, secretion, and degradation, and i...

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Detalhes bibliográficos
Main Authors: Li, Zhiqiang, Li, Yan, Chakraborty, Mahua, Fan, Yifan, Bui, Hai H., Peake, David A., Kuo, Ming-Shang, Xiao, Xiao, Cao, Guoqing, Jiang, Xian-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785386/
https://ncbi.nlm.nih.gov/pubmed/19648608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042028
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