Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

Sphingomyelin (SM) is one of the major lipid components of plasma lipoproteins. Serine palmitoyltransferase (SPT) is the key enzyme in SM biosynthesis. Mice totally lacking in SPT are embryonic lethal. The liver is the major site for plasma lipoprotein biosynthesis, secretion, and degradation, and i...

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Detaylı Bibliyografya
Asıl Yazarlar: Li, Zhiqiang, Li, Yan, Chakraborty, Mahua, Fan, Yifan, Bui, Hai H., Peake, David A., Kuo, Ming-Shang, Xiao, Xiao, Cao, Guoqing, Jiang, Xian-Cheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785386/
https://ncbi.nlm.nih.gov/pubmed/19648608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042028
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