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Myeloid cell–specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis

Serine palmitoyltransferase (SPT) is the first and rate-limiting enzyme of the de novo biosynthetic pathway of sphingomyelin (SM). Both SPT and SM have been implicated in the pathogenesis of atherosclerosis, the development of which is driven by macrophages; however, the role of SPT in macrophage-me...

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Bibliografski detalji
Glavni autori: Chakraborty, Mahua, Lou, Caixia, Huan, Chongmin, Kuo, Ming-Shang, Park, Tae-Sik, Cao, Guoqing, Jiang, Xian-Cheng
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613902/
https://ncbi.nlm.nih.gov/pubmed/23549085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60415
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