Myeloid cell–specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis

Serine palmitoyltransferase (SPT) is the first and rate-limiting enzyme of the de novo biosynthetic pathway of sphingomyelin (SM). Both SPT and SM have been implicated in the pathogenesis of atherosclerosis, the development of which is driven by macrophages; however, the role of SPT in macrophage-me...

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Главные авторы: Chakraborty, Mahua, Lou, Caixia, Huan, Chongmin, Kuo, Ming-Shang, Park, Tae-Sik, Cao, Guoqing, Jiang, Xian-Cheng
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613902/
https://ncbi.nlm.nih.gov/pubmed/23549085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60415
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