Myeloid cell–specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis

Serine palmitoyltransferase (SPT) is the first and rate-limiting enzyme of the de novo biosynthetic pathway of sphingomyelin (SM). Both SPT and SM have been implicated in the pathogenesis of atherosclerosis, the development of which is driven by macrophages; however, the role of SPT in macrophage-me...

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Bibliographic Details
Main Authors: Chakraborty, Mahua, Lou, Caixia, Huan, Chongmin, Kuo, Ming-Shang, Park, Tae-Sik, Cao, Guoqing, Jiang, Xian-Cheng
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613902/
https://ncbi.nlm.nih.gov/pubmed/23549085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60415
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