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Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B(4) synthetic capacity
The enzyme 5-lipoxygenase (5-LO) initiates the synthesis of leukotrienes from arachidonic acid. In resting cells, 5-LO can accumulate in either the cytoplasm or the nucleoplasm and, upon cell stimulation, translocates to membranes to initiate leukotriene synthesis. Here, we used mutants of 5-LO with...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC218730/ https://ncbi.nlm.nih.gov/pubmed/14530386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2133253100 |
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