Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase.

5-Lipoxygenase (5-LO) metabolizes arachidonic acid to leukotriene A4, a key intermediate in leukotriene biosynthesis. To explore the molecular mechanisms of its cell-specific localization, a fusion protein between green fluorescent protein (GFP) and human 5-LO (GFP-5LO) was expressed in various cell...

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Main Authors: Hanaka, Hiromi, Shimizu, Takao, Izumi, Takashi
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222333/
https://ncbi.nlm.nih.gov/pubmed/11802780
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