Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function.

1. The present study evaluated the time-dependency of acute anthracycline cardiotoxicity by varying the duration of exposure of rabbit isolated atria to doxorubicin and determining changes (1) in contraction and relaxation and (2) in atrial concentrations of doxorubicin and its C-13 hydroxy metaboli...

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Bibliographic Details
Main Authors: Mushlin, P. S., Cusack, B. J., Boucek, R. J., Andrejuk, T., Li, X., Olson, R. D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175809/
https://ncbi.nlm.nih.gov/pubmed/8298821
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