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Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function.

1. The present study evaluated the time-dependency of acute anthracycline cardiotoxicity by varying the duration of exposure of rabbit isolated atria to doxorubicin and determining changes (1) in contraction and relaxation and (2) in atrial concentrations of doxorubicin and its C-13 hydroxy metaboli...

詳細記述

保存先:
書誌詳細
主要な著者: Mushlin, P. S., Cusack, B. J., Boucek, R. J., Andrejuk, T., Li, X., Olson, R. D.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175809/
https://ncbi.nlm.nih.gov/pubmed/8298821
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