Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

Lignende værker

• Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.
  af: Mayer, U., et al.
  Udgivet: (1996)
• Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
  af: Schinkel, Alfred H., et al.
  Udgivet: (1997)
• Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
  af: van Asperen, J., et al.
  Udgivet: (1997)
• Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.
  af: Olson, R D, et al.
  Udgivet: (1988)
• Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function.
  af: Mushlin, P. S., et al.
  Udgivet: (1993)