Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active extrusion of a wide range of drugs from the cell. To study their physiological roles, we have generated mice genetically deficient in the mdr1b gene [mdr1b (−/−) mice] and in both the mdr1a and mdr1b genes [m...

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Detalhes bibliográficos
Main Authors: Schinkel, Alfred H., Mayer, Ulrich, Wagenaar, Els, Mol, Carla A. A. M., van Deemter, Liesbeth, Smit, Jaap J. M., van der Valk, Martin A., Voordouw, Arie C., Spits, Hergen, van Tellingen, Olaf, Zijlmans, J. Mark J. M., Fibbe, Willem E., Borst, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20562/
https://ncbi.nlm.nih.gov/pubmed/9108099
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