Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active extrusion of a wide range of drugs from the cell. To study their physiological roles, we have generated mice genetically deficient in the mdr1b gene [mdr1b (−/−) mice] and in both the mdr1a and mdr1b genes [m...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Schinkel, Alfred H., Mayer, Ulrich, Wagenaar, Els, Mol, Carla A. A. M., van Deemter, Liesbeth, Smit, Jaap J. M., van der Valk, Martin A., Voordouw, Arie C., Spits, Hergen, van Tellingen, Olaf, Zijlmans, J. Mark J. M., Fibbe, Willem E., Borst, Piet
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC20562/
https://ncbi.nlm.nih.gov/pubmed/9108099
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items