Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active extrusion of a wide range of drugs from the cell. To study their physiological roles, we have generated mice genetically deficient in the mdr1b gene [mdr1b (−/−) mice] and in both the mdr1a and mdr1b genes [m...

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Autors principals: Schinkel, Alfred H., Mayer, Ulrich, Wagenaar, Els, Mol, Carla A. A. M., van Deemter, Liesbeth, Smit, Jaap J. M., van der Valk, Martin A., Voordouw, Arie C., Spits, Hergen, van Tellingen, Olaf, Zijlmans, J. Mark J. M., Fibbe, Willem E., Borst, Piet
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC20562/
https://ncbi.nlm.nih.gov/pubmed/9108099
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