Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.

Doxorubicin (former generic name, adriamycin), a highly effective anticancer drug, produces cardiotoxicity, which limits its therapeutic potential. The mechanism of this cardiotoxicity has remained elusive. Our data suggest that this toxicity could involve doxorubicinol, the primary circulating meta...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Olson, R D, Mushlin, P S, Brenner, D E, Fleischer, S, Cusack, B J, Chang, B K, Boucek, R J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1988
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280258/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2897122/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3585
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