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Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.
Doxorubicin (former generic name, adriamycin), a highly effective anticancer drug, produces cardiotoxicity, which limits its therapeutic potential. The mechanism of this cardiotoxicity has remained elusive. Our data suggest that this toxicity could involve doxorubicinol, the primary circulating meta...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2897122/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3585 |
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