Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function.

1. The present study evaluated the time-dependency of acute anthracycline cardiotoxicity by varying the duration of exposure of rabbit isolated atria to doxorubicin and determining changes (1) in contraction and relaxation and (2) in atrial concentrations of doxorubicin and its C-13 hydroxy metaboli...

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Autores principales: Mushlin, P. S., Cusack, B. J., Boucek, R. J., Andrejuk, T., Li, X., Olson, R. D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175809/
https://ncbi.nlm.nih.gov/pubmed/8298821
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