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Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells
Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on serine 51 is effected by specific stress-activated protein kinases. eIF2α phosphorylation inhibits translation initiation promoting a cytoprotective gene expression program known as the integrated stress response (ISR). Stress...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173671/ https://ncbi.nlm.nih.gov/pubmed/14638860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308075 |
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