Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells

Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on serine 51 is effected by specific stress-activated protein kinases. eIF2α phosphorylation inhibits translation initiation promoting a cytoprotective gene expression program known as the integrated stress response (ISR). Stress...

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Bibliographic Details
Main Authors: Jousse, Céline, Oyadomari, Seiichi, Novoa, Isabel, Lu, Phoebe, Zhang, Yuhong, Harding, Heather P., Ron, David
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173671/
https://ncbi.nlm.nih.gov/pubmed/14638860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308075
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