A Subunit of Eukaryotic Translation Initiation Factor 2α-Phosphatase (CreP/PPP1R15B) Regulates Membrane Traffic

The constitutive reverter of eIF2α phosphorylation (CReP)/PPP1r15B targets the catalytic subunit of protein phosphatase 1 (PP1c) to phosphorylated eIF2α (p-eIF2α) to promote its dephosphorylation and translation initiation. Here, we report a novel role and mode of action of CReP. We found that CReP...

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Main Authors: Kloft, Nicole, Neukirch, Claudia, von Hoven, Gisela, Bobkiewicz, Wiesia, Weis, Silvia, Boller, Klaus, Husmann, Matthias
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471756/
https://ncbi.nlm.nih.gov/pubmed/22915583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.379883
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